Meanwhile, consistant with the results in the above, AKT1/2/3 and ERK1/2 phosphorylation was not inhibited with HHT treatment.To further examine the STAT3 phosphorylation in the xenograft tumor samples with different treatments, the tumor samples were frozen and cutted into 10 μm sections for fluorescent immunohistochemistry. The gene discussed is STAT3; the disease is neoplasm.