After 6 h with HHT treatment, IL-6-induced STAT3 phosphorylation in A549 and H1975 cells almost recovered which indicated that the HHT inhibition on STAT3 phosphorylation in lung cancer was reversible (Fig. 4I) and the recovery was not due to new synthesized STAT3 protein by CHX-treatment experiment (Fig. 4J). The gene discussed is STAT3; the disease is lung cancer.