Recent studies demonstrated that the possible mechanisms of HHT in anti-myeloma may be the inhibition of AKT phosphorylation and several AKT target genes including NF-κB, XIAP, cIAP and Cyclin D136 and inhibition of MCL1 protein synthesis and induction of apoptosis in chronic lymphocytic leukemia33. This evidence concerns the gene AKT1 and plasma cell myeloma.