Additionally, STAT3 constitutive activation promotes tumorigenesis partly through upregulation of certain antiapoptotic proteins expression including Bcl-xL, Bcl2, Survivin, and Mcl1, and has been discovered in a variety of hematological tumors and solid tumors including 22%~65% NSCLC. This evidence concerns the gene BCL2 and non-small cell lung carcinoma.