In the present study, we investigated gene expression profiles in the kidneys, and unexpectedly found that 6 SHRSP-specific genes isolated from the rats at 6 weeks of age (Banp, Ephx2, Rbfox1, Rxrg, Ryr1 and Zbtb16) were annotated to ‘Huntington's disease' (Table IV, G-4). Here, EPHX2 is linked to Huntington disease.