G-2 genes included 8 genes: angiotensin I converting enzyme (Ace), deiodinase, iodothyronine, type II (Dio2), acyl-Coenzyme A oxidase 2 (Acox2), fin bud initiation factor homolog (Fibin), flavin-containing monooxygenase 2 (Fmo2), indolethylamine N-methyltransferase (Inmt), myosin XVI (Myo16) and zinc finger and BTB domain containing 16 (Zbtb16) categorized as ‘cardiovascular disease (hypertension)' (Table IV, G-2) (22–24). The gene discussed is ZBTB16; the disease is hypertensive disorder.