Although these predicted interactions included the hypertension-related G-2 genes, Ephx2 and Zbtb16, they did not include other hypertension-related genes, such as Ace, Agtrap, Cftr, Glp1r, Kng2, Mylpf, Acox2, Dio2, Fibin, Fmo2, Inmt and Myo16 (Table II, G-2; GO:0003013, circulatory system process and Table IV, G-2; cardiovascular disease: hypertension). The gene discussed is DIO2; the disease is cardiovascular disorder.