CCND1 is a positive cell cycle regulator that is frequently overexpressed in MM and other cancers;[37, 38] BCL9 confers enhanced proliferation and metastatic properties to cancer cells;[39] HGF enhances migration and survival of MM cells;[40] WHSC1 promotes cell cycle progression and adhesion of MM cells.[41, 42] Furthermore, we show that the predicted targets could potentially be of prognostic significance, as it contains signature that strongly associated with patient survival in several myeloma datasets. The gene discussed is NSD2; the disease is plasma cell myeloma.