Gene Set Enrichment Analysis (GSEA) [25] of Molecular Signatures Database V3.0 showed significant enrichment of four gene sets in MM-normal phenotype comparison using the 215-gene list, including “genes downregulated in MM cell lines treated with demethylating agent decitabine and HDAC inhibitor TSA”,[26] which was consistent with miRNA target prediction since the downregulation could be attributed to the re-expression of miRNAs upon treatment, which in turn repressed the expression of their targets (Supplementary Table S5). The gene discussed is HDAC9; the disease is Miyoshi myopathy.