CCND1 is a positive cell cycle regulator that is frequently overexpressed in MM and other cancers;[37, 38] BCL9 confers enhanced proliferation and metastatic properties to cancer cells;[39] HGF enhances migration and survival of MM cells;[40] WHSC1 promotes cell cycle progression and adhesion of MM cells.[41, 42] Furthermore, we show that the predicted targets could potentially be of prognostic significance, as it contains signature that strongly associated with patient survival in several myeloma datasets. This evidence concerns the gene NSD2 and Miyoshi myopathy.