MYC and hepatocellular carcinoma: Luciferase reporter analysis indicated that co-expression of miR-451 significantly reduced the activity of firefly luciferase that carried wild-type but not mutant 3′-UTR of c-Myc, while restoration of miR-451 could downregulate the expression of c-Myc protein in HCC cells and the both xenografts and orthotopic lung implanted model tumors of miR-451-overexpressed HCC cells showed weaker staining of c-Myc protein (Supplementary Figure 4b-4d).