HIF1A and cancer: LDH-5 is composed of four LDH-A units which is overexpressed in many cancers including PDAC as a result of post-translational or transcriptional c-Myc, K-Ras, HIF-1α, and FOXM1 (forkhead box protein M1) dependent regulation, and is associated with poor prognosis [43, 123–126].