In addition, the encyclopedia of DNA elements (ENCODE) data also showed that TCF4 binds to a region of the human ID2 promoter that is homologous to the mouse Id2 enhancer in HCT116, a Wnt-signaling activated colon cancer cell line (Birney et al., 2007) (supplementary material Fig. S1). This evidence concerns the gene ID2 and malignant colon neoplasm.