The TRUMBI trial (Transcranial Low-Frequency Ultrasound-Mediated Thrombolysis in Brain Ischemia) was a phase II, prospective, multicenter nonrandomized trial that compared standard iv tPA vs. tPA plus low-frequency pulsed-wave transcranial ultrasound (300-kHz) in patients with defined arterial occlusion within a six hour time window. Here, PLAT is linked to brain ischemia.