EML4 and non-small cell lung carcinoma: The most amazing example was the anaplastic lymphoma kinase (ALK) story, in which the oral c-mesenchymal-epithelial transition (c-MET) and ALK inhibitor crizotinib was approved for patients with NSCLC harboring the echinoderm microtubule-associated protein-like 4 (EML4)-ALK rearrangement by the United States (US) Food and Drug Administration (FDA) in August 2011 and by the European Medicine Agency in Autumn 2012; this occurred just after an expansion of a phase 1 trial was successfully published in 2010 [12], although the EML4-ALK rearrangement in NSCLC was discovered in 2007 [13].