TNF and Immunodeficiency: We included members of known immune signaling pathways [Tumor Necrosis Factor (TNF), JAK/STAT, Immune Deficiency (IMD), Toll, Jun-N-terminal Kinase (JNK), and Vascular Endothelial Growth Factor (VEGF)], genes involved in hematopoiesis, putative immune recognition receptors, scavenger receptors, lysozymes and several genes with putative immune function.