In 931 subjects with ARDS enrolled in a randomized trial of liberal versus conservative fluid management, higher baseline angiopoietin-2 levels were strongly associated with increased mortality in noninfection-related ARDS, but not in infection-related ARDS, indicating that plasma angiopoietin-2 has differential prognostic value for mortality depending on the presence or absence of infection as an ARDS risk factor [59]. Here, ANGPT2 is linked to acute respiratory distress syndrome.