In the respiratory tract, Clca1-/- mice develop decreased levels of Cxcl-1, a potent neutrophil chemoattractant [75,76], and of Il-17, a proinflammatory cytokine [77] at the mRNA and protein levels with a consequent decrease in neutrophil response during Staphylococcus aureus pneumonia [47]. The gene discussed is IL17A; the disease is staphylococcus aureus pneumonia.