No novel variants that co-segregated with disease in the family trio were detected at any of the 19 other known loci for Mendelian forms of POAG (GLC1A-G, GLC1I-K, GLC1M-Q, GLC3A-D) including the eight known causative genes namely, MYOC (GLC1A), CYP1B1 (GLC3A), WDR36 (GLC1G), ASB10 (GLC1F), OPTN (GLC1E), NTF4 (GLC1O), TBK1 (GLC1P), and LTBP2 (GLC3C). The gene discussed is CYP1B1; the disease is open-angle glaucoma.