Four of these loci (GLC3A-D) have been linked with autosomal recessive primary congenital or infantile glaucoma (PCG), 15 loci (GLC1A-H, GLC1J, GLC1K-N, GLC1P-Q) with juvenile-onset (10–35 years) and/or adult-onset (>35 years) forms of autosomal dominant POAG, and two loci with adult-onset, complex POAG (GLC1I, GLC1O). Here, NTF4 is linked to open-angle glaucoma.