So far, linkage-based approaches have resulted in the discovery of eight causative genes for monogenic POAG namely, MYOC (GLC1A), OPTN (GLC1E), ASB10 (GLC1F), WDR36 (GLC1G), NTF4 (GLC1O), TBK1 (GLC1P), CYP1B1 (GLC3A), and LTBP2 (GLC3D). Here, ASB10 is linked to open-angle glaucoma.