NUCB2 and major depressive disorder: However, no correlations were detected between NUCB2/nesfatin-1 and depression (PHQ-9 score; r = -0.12, p = 0.52; Fig 1C), perceived stress (PSQ-20 total score; r = 0.05, p = 0.75; Fig 1D) as well as all PSQ-20-subscales (Table 2).