NUCB2 and depressive disorder: However, most likely these differential results in obese versus anorexic patients are due to a stronger association of NUCB2/nesfatin-1 with anxiety than depression or perceived stress that emerges when NUCB2/nesfatin-1 plasma levels are overall low as observed in the present anorexic population (0.22 ± 0.19 ng/ml) compared to obese women (0.40 ± 0.13 ng/ml) [19].