NUCB2 and Anxiety: The high anxiety group displayed 65% higher NUCB2/nesfatin-1 levels than the low anxiety group (0.28 ± 0.25 vs. 0.17 ± 0.07 ng/ml, p = 0.04; Fig 1A) which was reflected by a positive correlation of NUCB2/nesfatin-1 with GAD-7-scores in the whole study sample when treated as a continuous variable (r = 0.32, p = 0.04; Fig 1B).