To investigate the clinical outcome due to the over-expression of Flot-2 and EGFR in cancer tissues, we next investigated clinicopathological features of NSCLC including age, gender, clinical stages, lymph node metastasis (LNM) status, and pathological differentiation in univariate chi-square test. The gene discussed is FLOT2; the disease is metastatic malignant neoplasm in the lymph nodes.