During the multivariate analysis of the expression of Flot-2 and EGFR proteins in 159 lung SCC cases and 193 lung ADC cases, which included clinical stages, lymph node metastasis status, histological type, treatment strategy, age and gender, we have found that positive expression of Flot-2 protein may serve as an independent poor prognostic factor for lung ADC (P = 0.035), as well as clinical stages (P = 0.02). Here, EGFR is linked to metastatic malignant neoplasm in the lymph nodes.