Firstly, over-expression of both Flot-2 and EGFR were found in NSCLC; Secondly, positive relationship between the expression of Flot-2 and EGFR in NSCLC absolutely existed; At last, Flot-2 and EGFR might play an important role in promoting the development and progression of NSCLC. Here, FLOT2 is linked to non-small cell lung carcinoma.