INS and type 1 diabetes mellitus: DM has been clinically classified as insulin dependent diabetes mellitus (IDDM or type 1 DM/DM1) or non insulin-dependent diabetes mellitus (NIDDM or type 2 DM/DM2) based on decline in blood insulin level due to its poor secretion from β cells of islets of Langerhans in the pancreas or increased resistance of insulin leading to its poor targeting action on glucose metabolism, respectively followed by disturbances in the fat and protein metabolism [1].