GRIN1 and memory impairment: As per recent evidence, Bacopa monnieri alcoholic extract has been reported to possesses neuroprotective action by reversing the memory impairment due to pilocarpine treatment in rats by up regulating the expression of the NMDA glutamate receptor GluN1 subunit in the hippocampus [75] and activity of the NMDA receptor in the cerebral cortex [76].