In addition, pathways related to cardiac hypertrophy were also significantly activated, such as focal adhesion (P<0.01), the apoptosis pathway (P<0.01), the axon guidance pathway (P<0.01), neurotrophin signaling pathways (P<0.01), actin cytoskeleton regulation (P<0.01), hypertrophic cardiomyopathy (P<0.05), calcium signaling (P<0.05), and cardiac muscle contraction (P<0.05). The gene discussed is BDNF; the disease is cardiac hypertrophy.