CLN6 and juvenile neuronal ceroid lipofuscinosis: The thalamic changes we describe contrast with previous studies that report either no, or limited, histological changes in the thalamus in CLN6 Borderdale Batten disease sheep from the same flock reared under different conditions [15], although thalamic atrophy is present in another CLN6 (Merino) Batten disease sheep [12], the nclf mouse that has a natural disease-causing mutation in CLN6 [31] and in some late infantile Batten disease patients.