In “NICD—Control” group IRF6 mRNA expression was increased by 1.9-fold while ΔNp63 mRNA was decreased by 40% (Fig 6A) compared to “Control- Control” group, showing that double viral infection did not interfere with the effects of Notch activation on IRF6 and ΔNp63 expression. Here, IRF6 is linked to viral infectious disease.