H. pylori positivity did not associate with the TLR4 genotypes in the ulcer or non-ulcer dyspepsia patients’ groups or in the combined group; 62.1% (110/177) of the TLR4 homozygous wild type patients and 51.3% (20/39) of TLR4 heterozygous or homozygous mutant patients were H. pylori positive (p = 0.210). This evidence concerns the gene TLR4 and ulcer disease.