In line with the association with increased gastrin levels, we show that the TLR4 +896/+1196 homozygous wild types have an increased risk for peptic ulcers over the double mutant +896/+1196 allele carriers and the ulcer risk association was seen against the control group and the non-ulcer dyspepsia group. The gene discussed is TLR4; the disease is peptic ulcer disease.