The frequencies of IL-16 expressing microvessels were significantly (P < 0.0001) greater in hens with early stage OVCA (mean ± SD = 7.0 ± 1.29 in 20,000 μm2 of tumor tissue) than in normal hens (1.71 ± 0.49 in 20,000 μm2 of ovarian stromal tissue) and increased further (P < 0.0001) in hens with late stage of OVCA (10.33 ± 2.38 in 20,000 μm2 of tumor tissue) (Figure 5, bottom panel). The gene discussed is IL16; the disease is neoplasm.