The frequency of stromal IL-16 expressing cells was significantly (P < 0.0001) higher in hens with early stage OVCA (mean ± SD = 21.85 ± 5.42 in 20,000 μm2 of tumor tissue) than in normal hens (9.56 ± 4.87 in 20,000 μm2 of ovarian stromal tissue) and increased further in hens with late stage of OVCA (28.56 ± 5.08 in 20,000 μm2 of tumor tissue) (Figure 4, bottom panel). The gene discussed is IL16; the disease is neoplasm.