In the present study, we analyzed the associations between four putatively functional SNPs (rs28362491del>ins ATTG in NFκB1; rs12769316G>A in NFκB2; rs2233406C>T and rs696 G>A in IκBα) and NPC risk in 906 NPC patients and 1072 age and sex frequency-matched controls in southern Chinese, and then validated the remarkable findings with 684 NPC patients and 907 controls in eastern Chinese. This evidence concerns the gene NFKB1 and nasopharyngeal carcinoma.