It is reasonable about the fact that rs696G>A polymorphism might abolish the suppression of IκBα to NFκB1 and upexpression NFκB1 caused by rs28362491ins variants; these alterations in turn facilitated the carcinogenesis of NPC, which is potently supported our findings as gene-gene interaction of NFκB1 and IκBα polymorphisms contributing a detrimental role on NPC risk. This evidence concerns the gene NFKB1 and nasopharyngeal carcinoma.