In discovery set, we found that the rs28362491ins variant genotypes (ins/ins + ins/del) of NFκB1 conferred a 1.28-fold increased risk of NPC compared with del/del genotype (odds ratio [OR] = 1.28; 95% confidence interval [CI] = 1.01–1.63; P = 0.011) in a dominant genetic model, which is best fitted to criteria of the smallest AIC value. This evidence concerns the gene NFKB1 and nasopharyngeal carcinoma.