As a consistent harmful role of NFκB1 rs28362491del/ins and IκBα rs696G>A polymorphism for NPC risk, individuals carrying rs28362491ins variant genotypes had a 1.31-fold increased cancer risk compared with del/del genotype (OR = 1.31; 95% CI = 1.02–1.70; P = 0.009), and the rs696AA adverse genotype present a 1.38-fold risk of NPC compared to rs696 (GG + GA) genotypes (OR = 1.38; 95% CI = 1.09–1.75; P = 0.007). Here, NFKBIA is linked to nasopharyngeal carcinoma.