Gowda et al. [19] surprisingly found that the immunosuppressive cytokine IL-10, produced by Treg, T regulatory type 1 (Tr1) cells [24], and cells of the innate immunity, such as NK and macrophages, was elevated in PB of patients with low-risk NB, suggesting a protective role of innate immunity. The gene discussed is IL10; the disease is neuroblastoma.