Though the regulatory role of CXCL13 has been proven to mediate the activation of JNK and MAPK pathways [30, 31] in prostate cancer invasion and migration, its modulating acts on Wnt/β-catenin signaling in HCC and the effect of Wnt/β-catenin pathway on CXCL13 was still obscure. The gene discussed is CXCL13; the disease is Familial prostate cancer.