Th1 factors like IL-2, IL-6, TNF-α, and INF-γ, are linked to proinflammation, cytotoxic and cytophagic enhancement, and other antitumor functions, while Th2 factors, for example, IL-4, IL-10, and TGF-β, play a suppressive role in tumor immune microenvironment and promote tumor recurrence and metastasis. The gene discussed is TNF; the disease is neoplasm.