Indeed, GSK3 inhibitors can induce growth arrest or apoptosis in MM cell lines and can enhance the anti-MM cytotoxic effect of bortezomib, by modulating critical signaling pathways in these cells such as the forkhead transcription factors FHRL1 and FKHR, β-catenin, and extracellular signal-regulated kinase- (ERK-) 1/2 kinases. This evidence concerns the gene FOXO1 and Miyoshi myopathy.