We found that different drugs targeting the GSK3 kinase [e.g., lithium chloride (LiCl), SB216763 (SB21), or BIO] can upregulate both MICA protein surface and mRNA expression in MM cells, with little or no effects on MICB and PVR expression [63]; moreover, exposure to GSK3 inhibitors renders myeloma cells more susceptible to NK cell-mediated cytotoxicity. Here, MICA is linked to plasma cell myeloma.