Similarly, a previous study had demonstrated that STAT3 is a negative regulator of MICA transcription in different cancer cell lines [64]; moreover, GSK3 activity has been shown to positively influence the tyrosine705 (Tyr705) phosphorylation and DNA-binding activity of STAT3 in response to different cytokines, and inhibition of this kinase could significantly modulate the expression of STAT3-regulated genes [65]. This evidence concerns the gene STAT3 and cancer.