IGF1 and Miyoshi myopathy: In MM, Hsp90 inhibition has been shown to affect multiple client proteins involved in pathways critical to tumor development and progression, angiogenesis, and osteoclastogenesis, such as IGF1 and IL-6 receptors, and PI3K/Akt, STAT3, and MAPK signaling pathways; moreover, upregulation of Hsp90 has been observed in MM cells interacting with BMSCs [45–47].