Supporting a causal role of replication-associated damage in MLLbcr rearrangements, therapy-related t(11; 16)-AML with a MLL-CBP fusion was observed in a pre-B-cell ALL pediatric patient with FA (Sugita et al., 2000), and MLL partial tandem duplications (MLL-PTD) were reported in bone marrow samples from FA patients (Quentin et al., 2011). Here, KMT2A is linked to Friedreich ataxia.