Interestingly, myelodsyplastic syndrome (MDS) patients with the 11q23 rearrangement t(2; 11)(p21; q23) which does not affect the MLL gene but rather upregulates a downstream lying miRNA MIR125B1 resulting in inhibited primary human CD34+ cell differentiation, have a favorable prognosis (Bousquet et al., 2008; Dvorak et al., 2014). The gene discussed is KMT2A; the disease is myelodysplastic syndrome.