Moreover, the overexpression of MUC1 gene in human and murine mammary carcinoma cells correlates with the increase of T antigen assumedly by the concomitant down regulation of both C2GnT1 and ST3Gal (190), which also causes the loss of adhesive properties to E-selectin of the cells studied, but favors the binding of MUC1-overexpressing cells to galectin-3. This evidence concerns the gene LGALS3 and breast carcinoma.