LGALS3 and melanoma: Such interactions have been shown to mediate lung metastasis of melanoma cells through the adhesion of poly-LacNAc from N-glycans on galectin-3 (233) and to be important for tumor immune evasion, as demonstrated by the increase in tumor lymphocytic infiltration and tumor-specific cytotoxic T cells and decrease on melanoma growth in vivo after the treatment with a metabolic inhibitor of LacNAc biosynthesis (234).