KLK3 and Familial prostate cancer: To date, perhaps the most successful prostate cancer DNA vaccination platform is that of the PSA-targeting vaccine, PROSTVAC, consisting of a prime-boost strategy with recombinant vaccinia virus and fowlpox virus vectors expressing PSA and a triad of co-stimulatory molecules, B7.1, ICAM-1 and LFA-3, known as TRICOM [71].