In particular, about 50% of cutaneous melanomas harbour B-RAF V600E mutations [2] that are responsible for the increased phosphorylation of extracellular activated protein kinases (ERKs) and increased expression of cyclin D1, which is associated with progression through G1/S phase of the cell cycle, as a partner of cyclin-dependent kinases (cdks) [3]. The gene discussed is CCND1; the disease is melanoma.