Since glucocorticoids are involved in the pathogenesis of insulin resistance [31], these findings raise the possibility that ACTH- and glucocorticoid-induced changes in hsa-miR-27a expression might be relevant in the pathogenesis of various diseases, and most of all in hypercortisolism, but further studies are needed to establish the pathological relevance of these alterations. Here, POMC is linked to adrenal gland hyperfunction.