INS and type 2 diabetes mellitus: Studies on SUs revealed that these drugs might effectively act in response to the defect induced by KCNJ11 and ABCC8 mutations in T2D patients [17, 18]. KCNJ11 gene encodes the potassium inward rectifier 6.2 subunit (Kir6.2) of KATP channel, which is implicated in glucose-dependent insulin secretion in pancreatic β-cells.