MTHFR and coronary artery disorder: Similarly, recent literature meta-analyses of non DS-CHD cases revealed association of maternal MTHFR 677C>T and MTRR 66A>G polymorphisms with CHD risk in the offspring (Wang et al., 2013c; Cai et al., 2014), leading authors to hypothesize that methylation profiles and other epigenetic abnormalities could contribute to the etiology of heart malformations.