MTHFR 677CT or TT increased the risk for CHD: All MDS (OR = 2.07; 95% CI = 1.18–3.61), non users of folic acid supplements: (OR = 2.26; 95% CI = 1.25–4.09), users of folic acid supplements (OR = 1.07; 95% CI = 0.20–5.68).No association of CHD with the MTHFR 1298A>C polymorphism.No association of the studied polymorphisms with GI disease risk. This evidence concerns the gene MTHFR and coronary artery disorder.