MTHFR and myelodysplastic syndrome: Despite that those studies are often conflicting, most of them reported increased hcy levels or decreased measured or estimated folates in MDS with respect to control mothers (Table 3), and several authors observed association with the studied polymorphisms, including MTHFR 677C>T and 1298A>C polymorphisms that were often associated with increased hcy levels (James et al., 1999; O'Leary et al., 2002; da Silva et al., 2005; Martínez-Frías et al., 2006; Wang et al., 2007; Biselli et al., 2008b; Zampieri et al., 2012b).