Those meta-analyses also revealed that the frequency of the MTHFR 677T allele is higher in Caucasian MDS (ranging from 35.6 to 41.5%), followed by Brazilians (ranging from 33.5 to 33.9%), and lower in Asian populations (ranging from 20.0 to 32.3%) (Wu et al., 2013; Victorino et al., 2014). Here, MTHFR is linked to myelodysplastic syndrome.