We genotyped 172 MDS and 157 control mothers of Italian origin observing a decreased risk of birth of a child with DS in carriers of the DNMT3B -579T allele, with respect to GG carriers; moreover, the combined DNMT3B -579GT/-149CC genotype was associated with an even more significant reduced maternal risk of birth of a child with DS (Table 1) (Coppedè et al., 2013b). Here, DNMT3B is linked to Dravet syndrome.