No association was observed between the presence of either MTHFR 677C>T or MTHFR 1298A>C polymorphism in the mother and risk of DS-CHD offspring, and all MDS did not use folic acid supplements at peri-conception; similarly, the allele transmission of the two MTHFR polymorphisms showed no deviations from random segregation, leading the authors to conclude that none of the studied polymorphisms was associated with CHD risk in their cohort (Božović et al., 2011). Here, MTHFR is linked to coronary artery disorder.