ANNs revealed that micronucleus frequency and genotyping data for MTHFR 677C>T, TYMS 28bp repeats, TYMS 1494 6bp ins/del, MTR 2756A>G, and RFC1 80G>A polymorphisms, allowed to discriminate between MDS and control mothers with 90% accuracy (Coppedè et al., 2010). Here, RFC1 is linked to myelodysplastic syndrome.