DISC1 and mood disorder: One such gene of interest is Disrupted-In-Schizophrenia 1 (DISC1), which was initially identified at the breakpoint of a chromosomal translocation t(1;11)(q42.1;q14.3) that co-segregates with schizophrenia (Millar et al., 2000; Blackwood et al., 2001) and mood disorders (Hamshere et al., 2005; Hashimoto et al., 2006).