For the association between AXIN2 polymorphisms and lung cancer, the amount of evidence was categorized as B since its nminor was above 100 but less than 1,000 (n = 114), replication was assigned to category B with little between-study inconsistency (I2 < 50 %); and protection from bias was graded as category C due to the considerable potential for bias (only 3 studies). The gene discussed is AXIN2; the disease is lung carcinoma.