Chemerin acts as a chemotactic factor for ChemR23-expressing leukocyte populations, particularly macrophages, immature DCs, and NK cells, to promote their recruitment to localized sites of inflammation and tissue damage in conditions such as immunoglobulin E-mediated anaphylaxis, multiple sclerosis, and experimental autoimmune encephalomyelitis [19, 21, 32]. Here, RARRES2 is linked to multiple sclerosis.