The galectin-3-MUC1/4 interaction induces MUC1/4 cell surface polarization and results in the exposure of smaller cell surface adhesion molecules leading to increased adhesion of disseminating tumor cells to the vascular endothelium, and also increased aggregation of cancer cells resulting in the potential formation of circulating tumor emboli [9, 10]. This evidence concerns the gene LGALS3 and neoplasm.