LGALS3 and cancer: Suppression of galectin-3 expression was seen to be associated with a 38% reduction in the adhesion of these cells to HUVEC cells when compared with the galectin-3-expressing cells (Fig. 7B), confirming a role of cancer cell-associated galectin-3 in cancer cell-endothelial adhesion, as shown by several previous studies [36, 37].