Extracellular galectin-3 binds to cell surface N-glycans and induces monocyte and T cell apoptosis thus facilitating tumor cell evasion from immune surveillance [40, 41] whilst circulating galectin-3 promotes disseminating tumor cell adhesion to vascular endothelium and increases the formation of tumor microemboli thus prolonging tumor cell survival in the circulation [10]. Here, LGALS3 is linked to neoplasm.