Significant reductions in tumor numbers per lung, and lung weights were observed in the group of animals that were treated with heparin derivatives E (95 ± 38% reduction in galectin-3 induced metastasis, p = 0.001), E3 (106 ± 19% reduction in galectin-3 induced metastasis, p < 0.05) and F3 (161 ± 19% reduction in galectin-3 induced metastasis, p < 0.01) in comparison to the galectin-3 treated group (0 ± 18% reduction) (Fig. 3D and 3E). This evidence concerns the gene LGALS3 and neoplasm.