LGALS3 and cancer: Interaction of these low sulfated heparin derivatives with galectin-3 alter galectin-3 conformation and inhibit galectin-3-ligand binding, galectin-3-mediated cancer cell-endothelium adhesion and galectin-3-mediated angiogenesis in vitro and abolish circulating galectin-3-mediated increase of metastasis in vivo in a mouse model of cancer metastasis.