Indeed antagonism of miR-21 reduced RANKL mRNA (data not shown), both sRANKL (soluble RANKL) and mRANKL (transmembrane RANKL) protein expression levels in HS-5 adherent to MM cell lines (Figure 5A and 5B, left panels) as well as sRANKL secretion in cell-culture medium (Figure 5A and 5B, right panels) (p < 0.05). The gene discussed is TNFSF11; the disease is Miyoshi myopathy.