It has been reported the PI3K/Akt/mTOR signaling components were highly activated in glandular elements of colorectal carcinoma and colorectal adenomas with high-grade intraepithelial neoplasia [5], indicating that inhibitors of PI3K/Akt/mTOR signaling may serve as potential anti-CRC agents. The gene discussed is AKT1; the disease is intraepithelial neoplasia.