TGFB1 and melanoma: HF also has anticancer activity in bladder carcinoma by inhibiting tumor growth and metastasis through matrix metalloproteinase-2 [15, 16], prostate cancer [17], hepatocellular carcinoma [18], and also modulates the transforming growth factor beta (TGF-β) signaling pathway to inhibit acute promyelocytic leukemia as well as melanoma bone metastases [13, 19].