We also measured the mRNA expression of UCA1 by RT-PCR in 5 matched EGFR-mutant NSCLC specimens, including 2 with T790M and 3 without T790M(Table 2) (Figure 1C), both before treatment (BT) with EGFR-TKIs and after the development of resistance to TKIs, and found that UCA1 expression was up-regulated in patients with acquired resistance. Here, UCA1 is linked to non-small cell lung carcinoma.