RB1 and melanoma: Indeed, pretreatment with highly selective CDK4/6 inhibitors (PD-0332991 or 2BrIC) increased radioresistance of RB1-positive melanoma cells and immortalized fibroblasts [139], whereas combination treatments with radiation administered either concurrently or sequentially with PD-0332991 resulted in increased anticancer activity in mice with RB1-positive glioblastoma intracranial xenografts [140].