AKAP4 and non-small cell lung carcinoma: Although the number of nodules included in this analysis is relatively small, the AUC of the ROC curve for classifying all 264 NSCLC vs 27 samples from patients with benign nodules gave a value of 0.9825 (Figure 3B), the best performance of all tested classifications, suggesting that AKAP4 expression associated with PBMC has the potential to distinguish benign from malignant lung nodules, a possibility that needs to be further addressed in a larger study.