Since in our previous PBMC gene expression study [18, 19] we found that patients with lung squamous cell carcinomas (LSCC) were more accurately classified than those with lung adenocarcinomas (AC) and that classification accuracy also increased with advanced cancer stages, we then tested whether the strength of AKAP4 PCR signal also correlated with a variety of clinical parameters including cancer stage and subtype. The gene discussed is AKAP4; the disease is cancer.