NR1H3 and Myocardial fibrosis: Using two diverse hypertrophic perturbations, we demonstrated that constitutive LXRα activation countervailed pathological growth and remodeling processes in the heart, including blunting the development of myocardial fibrosis, an observation in line with previous studies demonstrating the anti-fibrotic effects of LXRs in kidney (Tachibana et al, 2012) and in liver (Beaven et al, 2011).