SLC2A1 and heart failure: Cardiac-specific overexpression of GLUT1 in mice increased glucose uptake and glycolysis which prevented the development of ventricular dysfunction and improved survival (Liao et al, 2002; Luptak et al, 2005), whereas reduced glucose utilization in GLUT4 knockout mice manifested greater hypertrophy and acceleration toward heart failure (Katz et al, 1995; Domenighetti et al, 2010).