GPT and familial hypercholesterolemia: For men, cardiometabolic risk factors that were associated with elevated ALT levels included age (OR,0.95; 95 % CI, 0.94–0.96), current smoking status (OR,0.62; 95 % CI, 0.52–0.75), hypertension (adjusted OR, 1.33; 95 % CI, 1.08–1.62), hypercholesterolemia (adjusted OR, 1.63; 95 % CI, 1.23–2.17), hypertriglyceridemia (adjusted OR, 1.62; 95 % CI, 1.25–2.09), BMI ≥25 kg/m2 (adjusted OR, 1.52; 95 % CI, 1.07–2.18), and hyperuricemia (adjusted OR, 1.92; 95 % CI, 1.54–2.40).