Mutations in GPR143 could affect melanin synthesis in the retinal pigment epithelium (RPE), and result in abnormal development of the retina and visual pathways, which could be the cause of the misrouting of the optic fibers, nystagmus, foveal hypoplasia, and reduced visual acuity10, 11, 12, 13, 14. Here, GPR143 is linked to Nystagmus.