FXIIIB was in fact found to be higher among South Asian ischemic stroke cases even after accounting for insulin resistance.29 However, as polygenic risk scoring approaches by design capture net genetic effects, the risk score based on FXIIIB-associated SNPs is the sum of many SNPs (of which the base change at the FXIIIVal34Leu polymorphism is just one), potentially acting both to increase and decrease levels of FXIIIB. Here, F13B is linked to ischemic stroke.