Three coagulation factors showed excess concordance (or discordance) of effect direction with stroke: SNPs significant at P≤0.3 in factor XIII subunit B (FXIIIB) were significantly discordant with the CE subtype (most significant P=5.7×10−04); SNPs significant at P≤0.05 through P≤0.2 in factor VIII (FVIII) were significantly concordant with the SVD subtype (most significant binomial P=6.5×10−04), but not at more liberal inclusion thresholds; SNPs significant at P≤0.3 only in Von Willebrand factor were significantly concordant with the SVD subtype. The gene discussed is F8; the disease is Stroke.