Networks 1 and 2 are illustrated in Fig. 3a and b and Additional file 2 A and B. Interestingly, the top networks involved in infectious diseases and inflammatory response were characterized by the activation of interferon regulatory factor 1 (IRF1), NF-κB2 and signal transducer and activator of transcription 2 (STAT2). Here, STAT2 is linked to infectious disease.