We crossed β3-integrin-wild-type (β3-WT) and β3-HET mice to tamoxifen (OHT)-inducible Pdgfb-iCreERT2/NRP1-floxed mice (Claxton et al., 2008; Gu et al., 2003) and examined the effect of an acute EC-specific depletion of NRP1 (EC-NRP1-KO) on subcutaneous allograft tumour growth with both CMT19T cells (Fig. 1A) and B16F0 cells (supplementary material Fig. S1), as well as on aortic ring sprouting (Fig. 1B). Here, PDGFB is linked to neoplasm.