Unlike the healthy genome, in which changes in gene expression are carefully controlled through transcription factors, the cancer genome adapts through the duplication of CD1C, CFHR3, FOXP2, MDFIC, RALYL, CSMD3, SAMD12-AS1, MAL2, and OR52N5, and loss in the coding regions of ADAM5, LOC400927, APOBEC3B, RPL3, MGAT3, SLC25A17, EP300, L3MBTL2, SERHL, POLDIP3, A4GALT, and TTLL1 genes. This evidence concerns the gene CFHR3 and cancer.