Apart from direct insertion into exons—as in the APC gene in a colon cancer [6]—they can terminate transcription by providing a polyA addition site, either the site used in creating the insert mRNA or, when in reverse orientation, an antisense polyA addition site about 0.5 kb from the 3’ end of the consensus L1 sequence [32]. This evidence concerns the gene APC and malignant colon neoplasm.