PPARG and obesity due to melanocortin 4 receptor deficiency: As expected, gene expression levels of Pparg in subcutaneous WAT and liver were positively associated with markers of obesity [body weight (r = 0.43, P < 0.001 and r = 0.70, P < 0.0001) or subcutaneous WAT/body weight (r = 0.35, P = 0.010 and r = 0.70, P < 0.0001)], fatty liver [liver weight/body weight (r = 0.43, P < 0.001 and r = 0.65, P < 0.0001) and intrahepatic TG (r = 0.40, P = 0.003 and r = 0.45, P = 0.001)].